Lymphocyte corticosteroid receptors (LCR) determining response to prednisone therapy in chronic active hepatitis (CAH)
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چکیده
منابع مشابه
Sulphasalazine treatment in hepatitis B virus (HBV) associated chronic active hepatitis (CAH)--a pilot study.
The optimum treatment of chronic active hepatitis (CAH) is unknown. Various immunosuppressive agents have been used in the past. The use of prednisolone has been found to be beneficial in patients with severe chronic active hepatitis. The criteria for treatment remain uncertain. Long term follow-up of chronic active hepatitis of moderate severity treated with prednisolone showed that hepatitis ...
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In view of promising, but uncontrolled, reports of the use of D-penicillamine in active chronic hepatitis, a randomised, prospective, controlled trial of this drug against prednisone was carried out. Of the 35 patients entered, 18 received D-penicillamine (increasing to 1-2 g daily) and 17 prednisone (15 mg daily). In all patients the disease had already been brought under biochemical control w...
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Transiliac biopsies from 34 female patients with corticosteroid treated chronic active hepatitis have been examined to determine the contributions made by decreased bone formation and increased bone resorption to bone loss associated with this condition and to determine the structural basis of the bone loss. Mean wall thickness was significantly reduced when compared with control values (p less...
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A study of lymphocyte cytotoxicity for rabbit hepatocyte cultures in 15 patients with untreated chronic active hepatitis showed positive results in all cases, both HBsAg positive and negative. After immunosuppressive therapy cytotoxicity became negative and remained negative, in four of nine patients followed serially. In 51 patients established on therapy for periods from three months to 12 ye...
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Children with uncontrolled autoimmune chronic active hepatitis have increased numbers of activated T lymphocytes expressing interleukin 2 receptors (IL2R). A soluble form of IL2R has recently been described whose proposed role is to downregulate T cell activation by competing for interleukin 2. We investigated whether a deficiency of soluble IL2R could account for the high concentrations of IL2...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1978
ISSN: 0016-5085
DOI: 10.1016/0016-5085(78)90634-0